Estro-Sense®
Estro-Sense® features high strength Indolplex® along with co-factors to help restore hormone balance

  60 Vcaps® (Vegetable capsules)*#
Estro-Sense® features 120mg of Indolplex® along with Fucus vesiculosus (Bladderwrack), selenium and vitamin D3 to support.

 

Practitioner Information

  • Estro-Sense® can assist female health conditions associated with oestrogen dominance. It is indicated in the relief of menopausal symptoms and medically diagnosed cyclical mastalgia and fibrocystic breast disease.
  • Estro-Sense® features Indolplex®, a unique and highly absorbable diindolylmethane as found in cruciferous sources with demonstrated clinical activity.[1],[2]
  • Indolplex® assists the favourable metabolism of oestrogen down the 2-hydroxylation pathway.[1],[3] A beneficial shift in metabolism can help maintain healthy oestrogen ratios and reduce the symptoms of oestrogen dominance. This is particularly important to assist breast health.
  • The active 2-hydroxyoestrone metabolites are considered the ‘good’ oestrogens.[4] Whereas the 4-hydroxyoestrone and 16-alpha-hydroxyoestrone metabolites are often termed the ‘bad’ oestrogens. Improved metabolism of available oestrogen allows healthy expression of this key hormone.
  • Indolplex® may assist breast health in women.[3],[5],[6],[7] This action is supported by iodine, selenium and vitamin D3.
  • Fucus vesiculosus (Bladderwrack) is a rich source of iodine. Mild iodine deficiency is common in Australia.[8],[9]
  • Iodine is a well studied mineral to help relieve the symptoms of fibrocystic breast disease.[10],[11],[12] The breast tissue concentrates iodine with an iodine deficiency associated with the development of breast health issues.[13]
  • Iodine is an essential element for the synthesis of triiodothyronine (T3) and thyroxine (T4), and is therefore required for normal thyroid function. Healthy thyroid activity assists favourable hydroxylation of oestrogen.[14]
  • Iodine deficiency leads to an increased sensitivity of breast tissue to oestrogen.[15] Iodine may also have a protective effect on the breast tissue by modulating oestrogen pathways.[16]
  • The incidence of benign and malignant breast disease is low in Japan when compared to the United States and other western countries.[17],[18],[19] It is suggested that a lower incidence is attributed to a higher intake of iodine from the traditional Japanese diet.[20] Seaweed and seafood consumption is a key source of iodine and is widely used in sushi, soups, salads and condiments.
  • Vitamin D3 (cholecalciferol) is the naturally occurring form of vitamin D. The biological effects extend far beyond controlling mineral metabolism. Vitamin D3 is now considered a ‘repair and maintenance’ pro-hormone that targets a wide variety of tissue.[21] Vitamin D3 supports overall health, including a healthy immune system.[21],[22] In Australia, the prevalence of vitamin D deficiency is widespread despite the abundance of sunshine.[23]
  • Studies support an association between iodine and vitamin D3 with improved breast health.[24] A deficiency of vitamin D is associated with an increased risk of both breast and ovarian disorders.[25]
  • Selenium is an essential micronutrient fundamental to health. It is a necessary component of several major metabolic pathways, including thyroid hormone metabolism, antioxidant defence systems and immune function.[26],[27],[28]

Each Vcap® Contains


Indolplex®                                                                         120mg

              Equiv. bioavailable DIM 36mg

Fucus vesiculosus (Bladderwrack) extract

              Equiv. dry herb                              362.5mg

              Providing iodine                                 145µg

Selenomethionine                                             250µg

  Equiv. Selenium                                 100µg

Cholecalciferol                                                11.5µg

              Equiv. vitamin D3                              460IU

 

Contains no gluten, soy, dairy, yeast, wheat, artificial flavours, colours or preservatives.


Directions For Use

Adults: Take 1 capsule a day or as directed by your healthcare practitioner.

 

Warnings
  • This product contains selenium which is toxic in high doses.  A daily dose of 150µg for adults of selenium from dietary supplements should not be exceeded. Selenium containing products are not suitable for children under the age of 15 years.
  • Do not use Indolplex® if you are pregnant, may become pregnant or are lactating. 

 Precautions & Considerations
  • Estro-Sense® contains iodine which can affect metabolism of thyroid hormones. Monitoring of individuals taking prescribed thyroid medication is recommended.
  • Harmless changes in urine colour may occur with Indolplex®. Increased water consumption can reduce this side effect.
  • Symptoms of nausea and/or headaches may occur with Indolplex®. Indolplex® assists activity of hepatic cytochrome P450 enzymes (CYP1A1/2) pathways. Nutrients required to support phase 2 liver detoxification pathways can assist in reducing these symptoms.
  • A short term increase in symptoms with Indolplex® may be due to increased metabolism of available oestrogen.
  • Indolplex® does not contain goitrogenic compounds which could affect thyroid function.
  • Indolplex® is not phytoestrogenic and has no inherent oestrogenic activity. Estro-Sense® can be used in used in conjunction with phytoestrogenic herbs.
  • Indolplex® may assist hormone health when taken with Hormone Replacement Therapy (HRT).
  • Indolplex® may assist hormone health when taken with the oral contraceptive pill (OCP).  Indolplex® has no inducing action on CYP3A4, the enzyme that metabolises the OCP. Therefore, Indolplex® does not affect efficacy of the OCP.
  • Indolplex® may assist effective metabolism of increased available oestrogen when taken with bioidentical hormone replacement therapy (BHRT).
  • Safety studies support concomitant use of Indolplex® with Tamoxifen.[29]
  • Combined use of Indolplex® and Zoladex is supported.
  • Concomitant use of Indolplex® with aromatase inhibitors is not recommended. This includes drugs such as Arimidex and Femara.
  • Indolplex® should be used with caution in patients taking anticoagulation medications.

References

[1] Zeligs MA. Safer Estrogen With Phytonutrition. Townsend Letter for Doctors and Patients. 1999; 189:83-88.

 

[2] Zeligs, MA. The Cruciferous Choice: Diindolylmethane or I3C? Phytonutrient Supplements For Cancer Prevention and Health Promotion. Townsend Letter for Doctors and Patients. August, 2001.

 

[3] Dalessandri KM, Firestone KM, Firestone GL, Fitch MD, et al. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutrition and Cancer. 2004;50(2):161-7.

 

[4] Bradlow HL, Telang NT, Sepkovic DW, Osborne MP. 2-Hydroxyestrone: the 'good' estrogen. J Endocrinol. 1996;150 Suppl:S259-265.

 

[5] Rahman KW, Sarkar FH. Inhibition of nuclear translocation of nuclear factor-{kappa}B contributes to 3,3'-diindolylmethane-induced apoptosis in breast cancer cells. Cancer Research 65. 2005 Jan 1;65(1):364-71.

 

[6] Rahman KW, Li Y, Wang Z, et al. Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells. Cancer Research 6. 2006 May 1;66(9):4952-60.

 

[7] Miller, K. Estrogen and DNA Damage: The Silent Source of Breast Cancer? J Natl Cancer Inst. 2003 Jan 15;95(2):100-2.

 

[8] Travers CA, Guttikonda K, Norton CA, et al. Iodine status in pregnant women and their newborns: are our babies at risk of iodine deficiency? Med J Aust. 2006 Jun 19;184(12):617-20.

 

[9] Li M, Eastman, CJ, et al. Are Australian children iodine deficient? Results from the Australian National Iodine Nutritional Study. Med J Aust. 2006 Feb 20;184(4):165-9.

 

[10] Ghent WR, et al. Iodine replacement in fibrocystic disease of the breast. Can J Surg 1993;36:453-460.

 

[11] Gaby, AR. Iodine treatment of fibrocystic breast disease. Townsend Letter for Doctors and Patients. 2004; 256: 24.

 

[12] Patrick L. Iodine: deficiency and therapeutic considerations. Altern Med Review. 2008 Jun;13(2):116-27.

 

[13] Aceves C, Anguiano B, Delgado G. Is iodine a gatekeeper of the integrity of the mammary gland? J Mammary Gland Biol Neoplasia. 2005 Apr;10(2):189-96.

 

[14] Michnovicz JJ, Galbraith RA. Effects of exogenous thyroxine on the C-2 and C-16 alpha hydroxylations of estradiol in humans. Steroids. 1990 Jan;55(1):22-6.

 

[15] Brownstein, D. Iodine: Why You Need It, Why You Can't Live Without It (3rd Edition). Medical Alternative Press. West Bloomfield, Michigan. USA. 2008: Page 76.

 

[16] Stoddard FR 2nd, Brooks AD, Eskin BA, et al. Iodine Alters Gene Expression in the MCF7 Breast Cancer Cell Line: Evidence for an Anti-Estrogen Effect of Iodine. Int J Med Sci. 2008 Jul 8;5(4):189-96.

 

[17] Yonemoto RH. Breast cancer in Japan and United States: epidemiology, hormone receptors, pathology, and survival. Arch Surg. 1980 Sep;115(9):1056-62.

 

[18] Stanford JL, Herrinton LJ, Schwartz SM, et al. Breast cancer incidence in Asian migrants to the United States and their descendants. Epidemiology.1995 Mar;6(2):181-3.

 

[19] Nomura Y, Kobayashi S, Takatani O, et al. Estrogen receptor and endocrine responsiveness in Japanese versus American breast cancer patients. Cancer Res. 1977 Jan;37(1):106-10.

 

[20] Cann SA, van Netten JP, van Netten C.Hypothesis: iodine, selenium and the development of breast cancer. Cancer Causes Control. 2000 Feb;11(2):121-7.

 

[21] Cannell JJ, Hollis BW, Zasloff M, et al. Diagnosis and treatment of vitamin D deficiency. Expert Opin Pharmacother. 2008 Jan;9(1):107-18.

 

[22] Cannell JJ, Hollis BW. Use of Vitamin D in Clinical Practice. Altern Med Rev. 2008 Mar;13(1):6-20.

 

[23] Nowson CA, Margerison C. Vitamin D intake and vitamin D status of Australians. Med J Aust. 2002 Aug 5;177(3):149-52.

 

[24] Cann SA, van Netten JP, van Netten C. Hypothesis: iodine, selenium and the development of breast cancer. Cancer Causes Control. 2000 Feb;11(2):121-7.

 

[25] Garland CF, Garland FC, Gorham ED, et al. The role of vitamin D in cancer prevention. Am J Public Health. 2006 Feb;96(2):252-61. Epub 2005 Dec 27.

 

[26] Rayman MP. The importance of selenium to human health. Lancet. 2000;356(9225):233-241.

 

[27] Ganther HE. Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66.

 

[28] Brown KM, Arthur JR. Selenium, selenoproteins and human health: a review. Public Health Nutr. 2001 Apr;4(2B):593-9.

 

[29] Zeligs MA, Fulfs JC, Peterson R, et al. In vivo, uterine-protective activity of absorption-enhanced diindolylmethane: Animal and preliminary human use in combination with Tamoxifen. Proc Am Assoc Cancer Res. 2003. 44:1268.


 

* VCAPS and the VCAPS logo are trademarks used under license
# This product is available in Queensland only

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